Employing gas sensors to detect specifical biomarker gases has become an important technique for early screening and non-invasive diagnosis of some diseases. In this work, aiming at the detection of specific iso propanol (IPA) in the breath of patients with bile acid diarrhea, a novel pyrochlore-Gd2Zr2O7-based solid state electrolyte type IPA sensor based on mixed potential sensing mechanism using ultrathin BiVO4 nanosheets as sensing electrode (SE) is developed. In the working temperature range of 400−500 °C, the response values of the prepared sensor present piecewise linear relationship with the logarithm of the concentration of 1−100 ppm IPA. At 500 °C, the sensitivities of the sensor to 1−5 ppm and 5−100 ppm IPA reach the maximum values of -7.5 mV/decade and -30.5 mV/decade, respectively. The fabricated sensor displays the low detection limit of 1 ppm IPA and repaid response/recovery time of 18/14 s to 100 ppm IPA at 500 °C. The developed IPA sensor also possesses good humidity resistance, reproducibility and stability within 10 days. More importantly, by distingushing the simulated volunteers for the breath components of patients with bile acid diarrhea and healthy people, the solid state electrolyte type IPA sensor opens up a promising prospect and may herald a new age of non-invasive diagnostics.