Metal-organic framework (MOF)-derived metal oxide semiconductors have received significant attention for gas sensing applications. Herein, we reported core-shell In2O3@ZnO n-n heterostructures by depositing ZIF-8 derivative onto wrinkled In2O3sphere, realizing the control of ZnO shell thickness (12.6–72.4 nm) through controlling MOF growth time. Due to the formation of n-n heterojunction at the core-shell interface, the tuning of shell thickness can lead to the radial modulation of the electron-accumulation layer in ZnO, and realizing the control of free charge carrier concentration that participated in gas sensing reaction. What’s more, the MOFderived ZnO shell with rich oxygen vacancies is beneficial for oxygen chemisorption. Accordingly, compared with the In2O3based sensor, the In2O3@ZnO based sensor exhibits higher sensitivity to trace-level acetone (100 ppb), faster response time (2 s vs. 100 ppm), better selectivity, and stronger anti-humidity capacity at operating temperature 300◦C, while the thickness of ZnO shell is 55.3 nm. In addition, the increase of ZnO shell thickness can lead to the selectivity change from ethanol to acetone of In2O3@ZnO owing to the inherent catalytic oxidation activity. Thus, the remarkable performance of the In2O3@ZnO sensor mainly relies on ZnO shell layer.