Flexible wearable electronic devices with multiple sensingfunctions that simulate human skin in all aspects have become a popularresearch topic. However, the current expensive and time-consumingmeans of integration and the complex decoupling process are hamperingthe further development of multifunctional sensors. Here, an ultraflexibleionic fiber membrane (IFM) prepared by a simple electrospinningtechnique is reported, which exhibits pressure and humidity sensingproperties. With the help of different electrode structures, the IFM-basedmultifunctional sensor achieved pressure and humidity detection withdifferent sensing mechanisms. Pressure sensing with high sensitivity (49.7kPa−1at 0−30 kPa) and wide detection range (0−220 kPa) was indicatedby the capacitive signal. Humidity sensing with high linearity (1.086% perpercent relative humidity (RH)) in the range 15%−90% RH was indicated by the resistance signal. In particular, the multimodaloutput of capacitance/resistance corresponding to pressure/humidity in this study directly addresses the problem of accuratelydistinguishing the two stimuli. Furthermore, we have demonstrated that the impact between pressure and humidity is negligiblewhen measured simultaneously and independently. Because of the excellent pressure/humidity sensing performance, we havefabricated a smart bracelet and mask for pulse, skin moisture, and breathe monitoring, which indicates the promising future ofmultifunctional flexible sensors based on IFM in the healthcare field.