Environmentally friendly degradable sen sors with both hazardous gases and pressure efcient sensing capabilities are highly desired for various prom ising applications, including environmental pollution monitoring/prevention, wisdom medical, wearable smart devices, and artifcial intelligence. However, the transient gas and pressure sensors based on only identical sens ing material that concurrently meets the above detection needs have not been reported. Here, we present transient all-MXene NO2 and pressure sensors employing three dimensional porous crumpled MXene spheres prepared by ultrasonic spray pyrolysis technology as the sensing layer, accompanied with water-soluble polyvinyl alcohol substrates embedded with patterned MXene electrodes. The gas sensor achieves a ppb-level of highly selective NO2 sensing, with a response of up to 12.11% at 5 ppm NO2 and a detection range of 50 ppb–5 ppm, while the pressure sensor has an extremely wide linear pressure detection range of 0.14–22.22 kPa and fast response time of 34 ms. In parallel, all-MXene NO2 and pressure sensors can be rapidly degraded in medical H2O2 within 6 h. This work provides a new avenue toward environmental monitoring, human physiological signal monitoring, and recyclable transient electronics.